The protective role of bilirubin in human beings
نویسندگان
چکیده
1. Professor of Medicine, Unit of Gastroenterology, Universidad Nacional de Colombia, Gastroenterologist, Clínica Fundadores, Clínica Carlos Lleras Restrepo and Fundación Hospital San Carlos, Bogota, Colombia 2. Internal Medicine Resident, Universidad Nacional de Colombia. Bogotá, Colombia. ........................................ Received: 21-07-09 Accepted: 18-08-09 Summary Bilirubin is more than just the fi nal product of heme catabolism. Today it is considered to be a fundamental substance which acts as an antioxidant and anti-infl ammatory agent in the serum. It can neutralize free radicals and prevent peroxidation of lipids. In addition there is evidence that it protects the cardiovascular system, neuronal systems, the hepatobiliary system, the pulmonary system and the immune system. Recently the use of pharmacological agents which augment expression of Heme oxygenase 1 (HO-1) has been investigated. Consequently its metabolites such as carbon monoxide (CO), biliverdin (BV) and bilirubin (BR) could become parts of a therapeutic strategy for treatment of various infl ammatory illnesses
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